Spenolimycin, a new spectinomycin-type antibiotic. III. Biological properties.
نویسندگان
چکیده
Spenolimycin is a new spectinomycin-type antibiotic isolated from Streptomyces gilvospiralis sp. nov. In vitro, it was active against a wide variety of aerobic Gram-positive and Gram-negative bacteria and Neisseria gonorrhoeae. It was two to four-fold more active against N. gonorrhoeae than spectinomycin. Spenolimycin was effective in the standard mouse protection test against Escherichia coli, Klebsiella pneumoniae and Streptococcus pneumoniae.
منابع مشابه
Spenolimycin, a new spectinomycin-type antibiotic. I. Discovery, taxonomy and fermentation.
Spenolimycin, a new spectinomycin-type antibiotic, was discovered in the fermentation broth of a new actinomycete named Streptomyces gilvospiralis sp. nov. strain AB634D-177. Although a small amount of spectinomycin is coproduced by strain AB634D-177, the culture is different from other known spectinomycin-producing actinomycetes. Spenolimycin was obtained by conventional submerged culture in 1...
متن کاملSpenolimycin, a new spectinomycin-type antibiotic. II. Isolation and structure determination.
A new water-soluble, basic antibiotic has been isolated from the fermentation beers of Streptomyces gilvospiralis sp. nov. The structure of the antibiotic has been deduced from spectral studies and confirmed by chemical degradation to spectinomycin. This structure, 3'-O-methylspectinomycin-3',4'-enol ether has led to the name spenolimycin.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 37 12 شماره
صفحات -
تاریخ انتشار 1984